ADJ. big, main, major, real, serious | minor, slight | obvious | possible, potential
VERB + DRAWBACK have (its/their), suffer from This strategy has its drawbacks. The system suffers from two major drawbacks. | overcome We have to find ways of overcoming these drawbacks.
PREP. ~ to Bad weather was the main drawback to camping in the far north. | ~ with The one big drawback with the planned scheme was its high cost.